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Auflistung Nach Schlagwort "Cholagogues and Choleretics"

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    • The challenges of primary biliary cholangitis: What is new and what needs to be done 

      Terziroli Beretta-Piccoli B., Mieli-Vergani G., Vergani D., Vierling J.M., Adams D., Alpini G., Banales J.M., Beuers U., Björnsson E., Bowlus C., Carbone M., Chazouillères O., Dalekos G., De Gottardi A., Harada K., Hirschfield G., Invernizzi P., Jones D., Krawitt E., Lanzavecchia A., Lian Z.-X., Ma X., Manns M., Mavilio D., Quigley E.M., Sallusto F., Shimoda S., Strazzabosco M., Swain M., Tanaka A., Trauner M., Tsuneyama K., Zigmond E., Gershwin M.E. (2019)
      Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ...

    • Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis 

      Cheung A.C., Lammers W.J., Murillo Perez C.F., van Buuren H.R., Gulamhusein A., Trivedi P.J., Lazaridis K.N., Ponsioen C.Y., Floreani A., Hirschfield G.M., Corpechot C., Mayo M.J., Invernizzi P., Battezzati P.M., Parés A., Nevens F., Thorburn D., Mason A.L., Carbone M., Kowdley K.V., Bruns T., Dalekos G.N., Gatselis N.K., Verhelst X., Lindor K.D., Lleo A., Poupon R., Janssen H.L.A., Hansen B.E., Global PBC Study Group (2019)
      Background & Aims: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences ...

    • Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis 

      Gatselis N.K., Goet J.C., Zachou K., Lammers W.J., Janssen H.L.A., Hirschfield G., Corpechot C., Lindor K.D., Invernizzi P., Mayo M.J., Battezzati P.M., Floreani A., Pares A., Lygoura V., Nevens F., Mason A.L., Kowdley K.V., Ponsioen C.Y., Bruns T., Thorburn D., Verhelst X., Harms M.H., van Buuren H.R., Hansen B.E., Dalekos G.N., Global Primary Biliary Cholangitis Study Group (2020)
      Background & Aims: Patients usually receive a diagnosis of primary biliary cholangitis (PBC) at an early stage, based on biochemical analyses. We investigated the proportion of patients who progress to moderate or advanced ...

    • Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin within the Normal Range and Normalization of Alkaline Phosphatase 

      Murillo Perez C.F., Harms M.H., Lindor K.D., Van Buuren H.R., Hirschfield G.M., Corpechot C., Van Der Meer A.J., Feld J.J., Gulamhusein A., Lammers W.J., Ponsioen C.Y., Carbone M., Mason A.L., Mayo M.J., Invernizzi P., Battezzati P.M., Floreani A., Lleo A., Nevens F., Kowdley K.V., Bruns T., Dalekos G.N., Gatselis N.K., Thorburn D., Trivedi P.J., Verhelst X., Parés A., Janssen H.L.A., Hansen B.E. (2020)
      INTRODUCTION:In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization of surrogate ...

    • Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis 

      Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)
      Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...

    • Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: Risk factors and time trends in incidence and outcome 

      Harms M.H., Lammers W.J., Thorburn D., Corpechot C., Invernizzi P., Janssen H.L.A., Battezzati P.M., Nevens F., Lindor K.D., Floreani A., Ponsioen C.Y., Mayo M.J., Dalekos G.N., Bruns T., Parés A., Mason A.L., Verhelst X., Kowdley K.V., Goet J.C., Hirschfield G.M., Hansen B.E., Van Buuren H.R. (2018)
      Objectives: In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion of patients. The aim of this study was ...

    • Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history 

      Murillo Perez C.F., Goet J.C., Lammers W.J., Gulamhusein A., van Buuren H.R., Ponsioen C.Y., Carbone M., Mason A., Corpechot C., Invernizzi P., Mayo M.J., Battezzati P.M., Floreani A., Pares A., Nevens F., Kowdley K.V., Bruns T., Dalekos G.N., Thorburn D., Hirschfield G., LaRusso N.F., Lindor K.D., Zachou K., Poupon R., Trivedi P.J., Verhelst X., Janssen H.L.A., Hansen B.E., on behalf of the GLOBAL PBC Study Group (2018)
      Changes over time in the presenting features and clinical course of patients with primary biliary cholangitis are poorly described. We sought to describe temporal trends in patient and disease characteristics over a 44-year ...

    • Primary biliary cirrhosis presented as peripheral eosinophilia in asymptomatic women with or without elevated alkaline phosphatase 

      Zachou, K.; Rigopoulou, E.; Liaskos, C.; Patsiaoura, K.; Makri, E.; Stathakis, N.; Dalekos, G. N. (2004)
      Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the destruction of biliary epithelial cells, presumably by autoimmune mechanism(s). Although lymphocytes play a pivotal role in the ...